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Diabetes
| What Is Diabetes? |
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Food is a source of energy for the body. Through
the process of digestion, most of the food that we consume is eventually
broken down into a simple sugar called glucose. Glucose then passes
into the bloodstream, where it becomes available for the body to
use for growth and energy. In order for glucose to be used by cells
in the body, a hormone produced by the pancreas, called insulin,
is needed.
In diabetes, the pancreas produces little or no insulin, or the
cells throughout the body are unable to utilize the insulin that
is being produced. The end result is a build-up of glucose in the
blood, which eventually spills over into the urine before leaving
the body. Elevated blood glucose levels are responsible for the
many health problems associated with diabetes.
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There are two main types of diabetes:
| Type 1 diabetes |
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- Also known as insulin dependent diabetes mellitus (IDDM) or
juvenile-onset diabetes
- In this type of diabetes the pancreas produces little or no
insulin
- Treatment always involves injections of insulin along with diet
modifications to control blood glucose levels
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| Type 2 diabetes |
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- Type II diabetes or NIDDM is far more common than type 1 and usually occurs in adulthood.
- In Type II diabetes, the pancreas does not make enough insulin to keep blood glucose levels normal
- Type II (NIDDM) is characterized by insulin resistance and sometimes progresses to loss of beta cell function.
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| Gestational diabetes |
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- This type of diabetes by definition affects pregnant women
- Treatment may involve diet alone or insulin injections to control
blood glucose levels
- This type of diabetes usually resolves once the pregnancy is over,
but women who experience gestational diabetes have a greater risk
for developing type 2 diabetes later in life.
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| How common is type 2 Diabetes? |
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| About 90% - 95% of all diabetic patients of Bangladesh belong to type
2 diabetes. |
| What are the risk factors for type 2 diabetes? |
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- Obesity. Many people with type 2 diabetes are obese, weighing
at least 20% more than what is recommended for their height. Insulin
resistance is known to increase when excess weight is added
- Heredity. Unlike type 1 diabetes, type 2 diabetes tends to run
in families
- Age. The risk for developing type 2 diabetes increases with age.
Half of all new cases of type 2 diabetes occur in persons age 55
or above
- Race. Compared with Caucasians and Asians, type 2 diabetes is
more common among Native Americans, African Americans, and Hispanics
- Sedentary Lifestyle. Insulin resistance increases with lack of
exercise
- Women who have had gestational diabetes. Women who develop gestational
diabetes during pregnancy have an increased risk of getting type
2 diabetes later on in life. Women who give birth to babies weighing
9 pounds or more at birth also have an increased risk of developing
type 2 diabetes
- Certain medications. The use of certain drugs, including thiazide
diuretics and steroids may contribute to the development of type
2 diabetes
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| What are the signs and symptoms of type 2 diabetes? |
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The symptoms of type 2 diabetes often develop gradually, may be
vague in nature, and often go unnoticed. The most common symptoms
associated with type 2 diabetes include:
- Increased fatigue
- Extreme hunger
- Excessive thirst
- Frequent urination (especially the need to get up during the night
to pass urine); unusual thirst
- Blurred vision
- Irritability
- Weight loss
- Frequent infections (especially urinary tract infections, boils,
and fungus infections)
- Erectile dysfunction (impotence)
- Slow healing of cuts and sores
Many people with type 2 diabetes are unaware that they have it. Others
find out only by having a routine screening blood sugar performed.
The American Diabetes Association (ADA) recommends that all adults
should have routine diabetes screening beginning at age 45 or younger,
if at risk. |
| How is type 2 diabetes diagnosed? |
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Testing for type 2 diabetes involves drawing blood samples and measuring the glucose (sugar) levels within the blood. Testing may be done when symptoms suggest the presence of diabetes or as a screening exam to detect unrecognized diabetes. Tests available for diagnosing type 2 diabetes include: |
| Random blood glucose |
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| During a normal glucose test, a sample of blood can be obtained and tested at any time. Normal random glucose levels are 70 to 110 mg/dl. According to the ADA, a random glucose level of greater than 200 mg/dl is indicative of diabetes. |
| Fasting plasma glucose test |
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| During a fasting plasma glucose test, a sample of blood is obtained following a period of not eating or drinking (except water) for at least 8 hours. It is usually drawn early in the morning, before breakfast. According to the ADA, a fasting blood glucose level of greater than 126 mg/dl on two occasions is indicative of diabetes. The fasting blood glucose test is the most common test in use for diagnosing diabetes. |
| Oral glucose tolerance test |
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| During an oral glucose tolerance test, a fasting blood sugar is
obtained initially. The person is then asked to drink a sweet sugary
beverage. Blood glucose levels are then obtained every 30 minutes
for the next 2 hours. A blood glucose level below 140 mg/dl at 2
hours is considered normal. A blood glucose level of greater than
200 mg/dl at 2 hours is indicative of diabetes. A blood glucose
level of 140 to 199 mg/dl at 2 hours indicates impairment in glucose
tolerance. These individuals should be monitored and screened for
diabetes in the future. |
| Urine glucose |
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| Once the blood glucose level begins to rise above 180 mg/dl, glucose
begins to spill over into the urine. This test is not diagnostic
for diabetes, but if there is sugar in the urine, a blood glucose
test should be performed. |
| Urine ketones |
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| Ketones are present in the urine when the body begins to breakdown
fat for energy. Ketones indicate that there is not enough insulin
present to prevent the mobilization of fat. The presence of ketones
can indicate a serious and potentially lethal complication of type
1 diabetes |
| Glycosylated hemoglobin |
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| This blood test is not used to diagnose diabetes, but rather to
give information about how well a blood glucose is being controlled.
It is a simple blood test that can be taken at any time. It will
give doctor important information that is needed to determine how
much insulin is needed to take or how diet may need to be altered
to keep diabetes under the best possible control. |
| How is type 2 diabetes managed? |
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| Although there is no cure for diabetes, there are several ways that
type 2 diabetes can be well managed. The ultimate goal of any treatment
for diabetes is to control blood glucose, to keep it within normal
limits to minimize the risk of later complications. The following
components are the cornerstone of successful type 2 diabetes management: - Diet modification
- Exercise
- Monitoring blood glucose levels
- Medications as needed
- Regular medical examinations by a doctor
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| Diet management |
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| The person with type 2 diabetes can enjoy the same foods as someone
without diabetes as long as they control calories and stay active
with exercise. If the persons are obese (weighing 20% more than
the weight recommended for height), they will be advised to try
to lose weight, since many people with type 2 diabetes can reduce
their blood sugar by weight loss and exercise alone. A nutrition
expert or dietitian can help to develop a personal nutrition plan
that is aimed at improving the nutrition habits, while recognizing
the need to enjoy food, too.
If a person is taking oral medications or insulin to control blood
glucose level, the timing of meals becomes very important. Skipping
or delaying meals can result in unhealthy fluctuations in blood
sugar levels and can lead to serious diabetic reactions. In general,
the aims of dietary advice are:
- Achieve and maintain desirable body weight
- Provide optimal nutrition
- Achieve normal or near normal blood sugar and lipid levels
- Avoid refined sugar, molasses, gur
- Encourage high fiber diet- vegetable, legumes, whole gram,
fruits
- Minimum use of saturated fats e.g., animal fat, dairy products,
butter, ghee, coconut products etc
- Food intake must be distributed evenly throughout the day
except during the days of fasting (ramazan)
- Artificial sweetners containing sorbitol or fructose is discouraged,
non-caloric sweetner e.g., aspartame, saccharine may be used
- Reduce salt intake- if hypertension is present
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| Exercise |
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Being overweight makes type 2 diabetes more difficult to control,
so maintaining a healthy weight is an important part of treatment.
Staying active and getting some form of regular exercise will help
people with diabetes to not only manage their weight, but also to
lower their blood sugar and thus reduce their overall risk of developing
some of the long-term complications associated with diabetes.
The amount of exercise that is right for someone with type 2 diabetes
will be based on many factors like age, weight, lifestyle, other
existing health problems, and previous experience with exercise.
All persons diagnosed with type 2 diabetes should have a complete
physical examination by a doctor before starting any new exercise
program.
Increasing the daily physical activity does not mean that the people
will have to "work out" at a gym or health club. There
are many activities that can be incorporated into daily routine
that will go along way toward increasing physical activity. The
examples that can be considered are: taking the stairs instead of
the elevator, parking farther away from store entrances, enlisting
a group of friends to take a daily walk, mowing the lawn or weeding
the garden, going on bowling, or visiting a museum. Starting slowly,
perhaps aiming for 15 minutes of increased physical activity per
day is a realistic goal. |
| Monitoring blood glucose levels |
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All people with type 2 diabetes need to have their blood glucose
levels monitored, since the single most important factor in managing
type 2 diabetes is achieving tight glucose control.
Many of those with type 2 diabetes learn how to monitor their blood
glucose levels at home, while others have their glucose levels checked
regularly by their doctor. Home glucose monitoring involves taking
a small sample of blood from the fingertip, placing it on a special
strip, and waiting for a machine to read the glucose levels. This
can be as quick as 5 seconds. The doctor can advise about how often
a person needs to check blood glucose levels.
Based on the results of blood glucose levels, the doctor will recommend
changes to diet, exercise plan, and diabetic medications.
Medications
While some people with type 2 diabetes can manage their disease
with diet and exercise alone, others will require medication. Oral
medications prescribed alone or in combination, with or without
insulin injections, are all possible ways that the doctor might
treat type 2 diabetes.
Most oral medications used to treat type 2 diabetes work by increasing
insulin production, decreasing glucose production, or enhancing
the body's ability to use its own insulin more effectively. There
are many different oral medications available to treat diabetes.
The individual with type 2 diabetes will need to inject insulin
when their pancreas is no longer able to produce the insulin needed
to regulate blood glucose levels. Insulin may be needed from the
onset of type 2 diabetes, or it may become necessary later on, as
the disease progresses.
Most patients with diabetes, who require insulin, learn to administer
their own insulin after learning the proper techniques for insulin
preparation and injection. The doctor will decide which type of
insulin and how much is needed, based on theblood glucose levels.
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| New insulin options |
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The 62nd Annual Scientific Session of the American Diabetes
Association (ADA) stated that there would be new options for diabetic
patients who take insulin injections. Some new options are pills,
a transdermal skin patch, a mouth spray, and several types of pulmonary
inhaled insulin. A pill, now in clinical trials, uses polymer technology
to avoid degradation and make it more absorbent into the bloodstream.
The skin patch is battery-powered. When it is put on the skin it
vaporizes cells on the skin's surface, creating "microscopic"
openings through which insulin is absorbed during 12 hours of wear.
Scientists are still testing the effectiveness of an oral spray
for insulin which resembles a metered dose inhaler used by asthmatic
patients. When perfected the insulin spray would be put directly
into the lungs. |
| Regular medical examinations by a doctor |
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| An important part of the overall treatment plan with type 2 diabetes
is regular medical examinations by a doctor who is experienced in
treating diabetes type 2 patients. Maintaining tight blood glucose
control and getting regular checkups and screenings can prevent
many of the complications associated with diabetes. |
| What is a diabetic reaction and how is it treated? |
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Hypoglycemia is a potentially serious side effect of diabetes management
that can occur in diabetics when taking oral medications and/or
insulin. It results when the level of glucose in the blood falls
to an abnormally low level. More severe hypoglycemia can occur suddenly,
causing unconsciousness or seizures. This type of hypoglycemia is
a medical emergency.
The following signs and symptoms often accompany mild hypoglycemia:
- Anxiety
- Tremors or shaky feelings
- Sweating or warm feeling inside
- Hunger
- Nausea
- Rapidly beating heart
- Mental confusion or difficulty concentrating
- Dizziness
- Headache
The following signs and symptoms often accompany more severe hypoglycemia:
- Slurred speech
- Disorientation
- Confusion and irrational behavior
- Loss of consciousness
- Seizures
The treatment for hypoglycemia is glucose. Glucose is necessary
to raise the blood sugar to a normal level. If the patient is awake
and alert, he or she can ingest a food or drink that contains about
15 to 20 grams of carbohydrate. Good choices would include 6 ounces
of fruit juice or cola product, about 7 lifesaver candies, or 14
ounces of milk. After ingesting one of these foods, it will take
about 10 to 15 minutes for the blood glucose level to rise.
Severe hypoglycemia, that renders a diabetes patient unconscious,
must be treated with an injectable form of glucose. Some people
carry an injectable form of glucose called glucagon. Glucagon stimulates
the liver to release glucose.
A family member or friend can give this injection at home, or wherever
the reaction occurs. If glucagon is not available, or does not raise
the blood sugar enough, emergency personnel will administer an intravenous
injection of concentrated glucose. This will result in a rapid rise
in blood sugar. |
| How can the complications of type 2 diabetes be prevented? |
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The most important factors in reducing the risk of developing complications
associated with diabetes include maintaining tight blood glucose
control and having regular checkups with your doctor. It's no secret
that a person with diabetes is at greater risk for other health
problems; however, studies have shown that many of these problems
can be prevented or successfully treated when they are identified
early on.
Aggressive treatment of diabetes, beginning as soon as possible
after diagnosis, reduces complications and prolongs health. The
Diabetes Control and Complications Trial (DCCT), a clinical study
conducted from 1983 to 1993 by the National Institute of Diabetes
and Digestive and Kidney Diseases (NIDDK) in United States showed
that keeping blood glucose levels as close to normal as possible
slows the onset and progression of eye, kidney, and nerve diseases
caused by diabetes. |
| Cardiovascular and cerebrovascular disorders |
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Heart disease is the number one cause of death in the United States,
accounting for about one third of all deaths. It is even a greater
threat since two thirds of people with diabetes die of heart or
blood vessel disease. Those with diabetes are also about five times
more likely to have a stroke than their nondiabetic counterparts.
In addition to controlling their blood glucose levels, people with
diabetes must be aware of other factors that can play a role in
preventing the cardiovascular and cerebrovascular complications
of diabetes. These include not smoking, maintaining normal blood
pressure and blood cholesterol levels, eating a low-fat diet, and
getting regular exercise. These lifestyle factors are particularly
important for people with type 2 diabetes. |
| Eye disorders |
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People with diabetes are at increased risk for developing eye problems,
the most common of which is a condition called diabetic retinopathy.
Retinopathy is caused by damage to the blood vessels that nourish
the nerves within the retina. Retinopathy is the leading cause of
blindness in diabetes. All patients with type 2 diabetes are encouraged
to have an annual eye exam to screen for this disorder.
Patients with diabetes also are at increased risk for developing
cataracts, caused by clouding of the lens of the eye, and glaucoma,
caused by an increase in fluid pressure within the eye that damages
the optic nerve. Annual eye exams can detect both of these conditions.
Cataracts can be corrected surgically and glaucoma can be treated
with eye medication. |
| Nervous system disorders |
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Diabetic nerve damage called neuropathy affects up to 65% of those
with diabetes. Diabetic neuropathy can cause a variety of symptoms
including pins and needles sensation in the hands and legs, or a
loss of pain sensation in the extremities (which can contribute
to foot problems). Neuropathy can also affect the bladder, bowel,
stomach and skin, as well as cause sexual dysfunction for those
with diabetes. The most common type of neuropathy is peripheral
which can affect the arms and legs and result in amputation.
The best way to prevent diabetic neuropathy is to practice tight
blood glucose control. Statistics show that a person can reduce
the risk of neuropathy by 69% if he/she maintains tight control
over blood sugars. |
| Kidney disorders |
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Kidney damage called nephropathy occurs more commonly with diabetes
and is the leading cause of end stage renal disease associated with
diabetes. The earliest sign of kidney damage begins when protein
begins to spill over into the urine. This can be detected by a simple
urine test that should be performed regularly as part of a diabetes
health screening.
Although heredity plays a role in the development of kidney problems
for patients with diabetes, other factors like controlling blood
pressure, reducing protein intake in the diet, and maintaining tight
control of blood glucose levels can reduce the risk of kidney complications
associated with diabetes.
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| Infection |
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People with diabetes run an increased risk of developing many types
of infections. This risk is directly related to increased glucose
levels, which provide an ideal environment for many disease-causing
organisms and also hamper the immune system's ability to fight off
infections.
The best way for the person with diabetes to avoid infections is
to practice tight control of blood glucose levels. Patients with
diabetes should also closely examine their skin (especially their
feet) for any evidence of breakdown or ulceration. Many diabetes
patients have decreased sensation in their extremities, and it is
possible for them to have foot ulcers without experiencing any pain.
Practicing good oral hygiene and visiting the dentist regularly
can help some one with diabetes to avoid infections of the gums
and mouth.
In diabetes, all cuts and open wounds deserve special attention.
Be certain to wash any area of skin breakdown thoroughly with soap
and water and monitor the area each day for evidence of infection
(redness, warmth, pus, or other drainage and fever are all signs
of infection). |
| How often does a person need to see a doctor? |
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How often a person will need to visit a doctor will depend on various
factors such as how close to normal the blood glucose levels are,
what symptoms a person may be experiencing, what other health conditions
are being treated for, and how comfortable the person is with current
treatment plan for managing diabetes.
The American Diabetes Association recommends that all patients with
type 2 diabetes should visit their doctor at least 2 to 4 times
per year. If the patient is newly diagnosed or experiencing symptoms
he/she may need to visit the doctor more often.
During each doctor visit the patient should be prepared to discuss
about blood glucose readings. The doctor will record the weight
and blood pressure at each visit. As part of routine physical examination
the doctor will also check the eyes and feet to screen for diabetic
complications. An annual examination by an eye doctor is also recommended.
Several blood tests to check cholesterol, lipids, and glycosylated
hemoglobin (a blood test that gives information about how well controlled
the blood sugars have been during the last 2 to 3 months) may also
be done. A urine test should also be performed to check for protein.
During each office visit, the patient should have an opportunity
to review treatment plan and set goals together with physician.
It should be remembered that diabetes management is a joint effort
that will only produce good results when both the patient and doctor
work together cooperatively. |
The commonest manifestation is an itchy rash that develops over a few days, after skin contact with a substance. The affected area first becomes itchy, then red and swollen with vesicles (water bubbles).
Although usually confined to the area of contact, sometimes strikingly so the rash can spread to other parts of the body.
occasionally the rash is more chronic, manifesting as an itchy patch that does not heal for weeks or even months. This usually occurs when there is frequent contact with the substance e.g. a watch strap. The rash resulting from contact allergy is called allergic contact dermatitis. |
A substance that can cause contact allergy is called a contact allergen. Common contact allergens are:
- metals e.g. nickel in watch straps, chrome in cement
- skin care products e.g. fragrances, lanolin
- medication e.g. flavine, neomycin.
A skin test called a patch test is used to confirm contact allergy. The upper back is used as a test site. A small amount of the suspected contact allergen (diluted to a non-irritant concentration) is applied onto the skin in an aluminium chamber and sealed with hypoallergenic tape. Usually, several suspected allergens are tested simultaneously. They are left on the skin for 48 hours and read at 48 and 96 hours. A positive reaction indicates that he patient is allergic to the test substance. This is a very safe procedure. |
Very often it is. An example of the need for a patch test is when a skin rash has persisted for a long time. Many skin care products and medication would have been tried. It is necessary to identify the cause of contact allergy. A patch test will help to ascertain the cause.
Another situation whereby a patch test is important is when a dermatitis is suspected to be due to work. There are many substances in the workplace that may cause contact allergy. |
In many cases, removing the cause i.e. the allergen from skin contact will result in a cure. Usually, once allergy to a substance has developed, it remains for life. That is to say, future contact with the substance will result in an allergic contact dermatitis again. This is exactly like a drug allergy. It is advisable for patients to carry a card to remind themselves and their doctors of their contact allergy. |
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