Tobasol® Respirator Solution is an aqueous solution of Tobramycin. Tobramycin is an aminoglycoside antibiotic and acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, and eventual cell death. Tobramycin is bactericidal and is active against wide range of Gram-negative organisms including Pseudomonas aeruginosa.
Tobasol® Respirator Solution is indicated for the management of cystic fibrosis patients with Pseudomonas aeruginosa. Also indicated for severe COPD patients colonized with Pseudomonas aeruginosa.
- Improves lung function (FEV1)
- Reduces days spent in hospital (37% fewer days in hospital)
- Reduces the need for IV antipseudomonal antibiotics (32% fewer days receiving IV antipseudomonal antibiotics)
- Significantly decreases sputum bacterial density of Pseudomonas aeruginosa